Lysine lactylation kla
Web4 nov. 2024 · Lysine lactylation (Kla) has recently been reported to participate in regulating transcription in human cells. However, the characterization, regulatory mechanism and functional consequence of... WebRecently, lysine lactylation (Kla), a novel post-translational modification (PTM), which can be stimulated by lactate, has been found to regulate gene expression and life activities. Therefore, it is imperative to accurately identify Kla sites. Currently, mass spectrometry is the fundamental method …
Lysine lactylation kla
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Web17 iun. 2024 · Kla is a newly discovered histone post-translational modification (PTM) that plays important roles in regulating gene expression. However, Kla in non-histone … Web10 aug. 2024 · FSL-Kla: A few-shot learning-based multi-feature hybrid system for lactylation site prediction Comput Struct Biotechnol J. 2024 Aug 10;19:4497-4509. doi: 10.1016/j.csbj.2024.08.013. eCollection 2024. Authors Peiran Jiang 1 2 , Wanshan Ning 3 , Yunshu Shi 1 4 , Chuan Liu 5 , Saijun Mo 1 , Haoran Zhou 1 , Kangdong Liu 1 6 7 , …
Web27 mai 2024 · Background Metabolites such as crotonyl-CoA and lactyl-CoA influence gene expression through covalently modifying histones, known as histone lysine crotonylation (Kcr) and histone lysine lactylation (Kla). However, their existence patterns, dynamic changes, biological functions, as well as associations with histone lysine acetylation … Web15 apr. 2024 · Lactylation Characteristics and functions of Kla Lactate-derived Kla is a newly identified PTM that closely couples metabolism, especially the ‘Warburg effect’, with epigenetic modification. Under lactate increases induced by hypoxia and bacterial challenges, histone Kla is stimulated and directly promotes gene transcription [ 21 ].
Web12 oct. 2024 · This study investigates whether lysine lactylation (Kla), a lactate-derived post-translational modification in macrophages, occurs in brain cells and if it does, … Web3 mar. 2024 · Recently, lysine lactylation (Kla), a novel post-translational modification (PTM), which can be stimulated by lactate, has been found to regulate gene …
WebRecent research identified lysine lactylation (Kla) as a post-translational modification that can be stimulated by lactate ( Zhang et al., 2024 ). The report suggested that lactate modulates metabolic-alteration-related gene expression through histone H3 Kla in mouse macrophages ( Zhang et al., 2024 ).
WebSKU: PTM-1401 Categories: Lysine Lactylation, Pan PTM Antibody Tags: Kla, lactylated, PTM-1401 Description Reviews (0) Product Description Size: 100 μl Host Species: Rabbit Clonality: Polyclonal Immunogen: … eliza kroezeWeb1 oct. 2024 · Lysine lactylation (Kla) is a newly discovered histone post-translational modification (PTM), playing important roles in regulating transcription in macrophages. However, the extent of this PTM in ... tedi kunstnägeltedi loomWeb27 feb. 2024 · Lactylation and delactylation influence various physiological and pathological processes via epigenetic regulation and other mechanisms. For instance, lysine … eliza knoxWeb19 ian. 2024 · Lysine L-lactylation [K(L-la)] is a newly discovered histone mark stimulated under conditions of high glycolysis, such as the Warburg effect. K(L-la) is associated with functions that are different from the widely studied histone acetylation. ... Thus, here, unless specified, all the Kla and lactylation will suggest the L-isomer instead of the ... tedi kunstblutWeb26 aug. 2024 · Of particular note, central nervous system-intrinsic microglia are highly similar to macrophages, which can also be regulated by protein lactylation. An updated study showed increased levels of Pan-lysine lactylation (Pan Kla) and H4K12la in both Alzheimer’s disease (AD) mouse models and human AD brain tissues (Pan et al., 2024). tedi madridWeb17 iun. 2024 · Identification of lysine-lactylated substrates in gastric cancer cells Identification of lysine-lactylated substrates in gastric cancer cells iScience. 2024 Jun 17;25 (7):104630. doi: 10.1016/j.isci.2024.104630. eCollection 2024 Jul 15. Authors Dawei Yang 1 , Jie Yin 2 , Liuqun Shan 3 , Xingling Yi 4 , Wei Zhang 5 , Yongbin Ding 6 3 Affiliations tedi landstuhl